Publications de l’équipe 4CS depuis 2011

Scientific publications in peer reviewed journals


  1. Boucher J, Simonneau C, Denet G, Clarhaut J, Balandre AC, Mesnil M, Cronier L, Monvoisin A. Pannexin-1 in Human Lymphatic Endothelial Cells Regulates Lymphangiogenesis. Int J Mol Sci. 2018 May 24;19(6). pii: E1558. doi: 10.3390/ijms19061558.
  2. Graham SV, Jiang JX, Mesnil M. (2018) Connexins and Pannexins: Important Players in Tumorigenesis, Metastasis and Potential Therapeutics. Int J Mol Sci. 2018 Jun 1;19(6). pii: E1645. doi: 10.3390/ijms19061645.
  3. Sarrouilhe D, Mesnil M, Dejean C. (2018) Targeting Gap Junctions: New Insights in the Treatment of Major Depressive Disorder. Curr Med Chem. 2018 Mar 26. doi: 10.2174/0929867325666180327103530. [Epub ahead of print]
  4. Cabanas H, Harnois T, Magaud C, Cousin L, Constantin B, Bourmeyster N, Déliot N. (2018) Deregulation of calcium homeostasis in Bcr-Abl-dependent chronic myeloid leukemia. Oncotarget, 2018; 9:26309-26327.
  5. Domenichini F, Terrié E, Arnault P, Harnois T, Magaud C, Bois P, Constantin B, Coronas V. (2018) Store-Operated Calcium Entries Control Neural Stem Cell Self-Renewal in the Adult Brain Subventricular Zone. Stem 2018 Jan 23. doi: 10.1002/stem.2786 (IF : 7.5)
  6. Péraudeau E, Cronier L, Monvoisin A, Poinot P, Mergault C, Guilhot F, Tranoy-Opalinski I, Renoux B, Papot S, Clarhaut J (2018). Enhancing tumor response to targeted chemotherapy through up-regulation of folate receptor α expression induced by dexamethasone and valproic acid. J Control Release. Jan 10;269:36-44.
  7. Yefimova MG, Messaddeq N, Meunier AC, Cantereau A, Jegou B, Bourmeyster N. (2018) Phagocytosis by Sertoli Cells: Analysis of Main Phagocytosis Steps by Confocal and Electron Microscopy. Methods Mol Biol.;1748:85-101.
  8. Hervé JC, Bourmeyster N (2018). Rab GTPases, master controllers of eukaryotic trafficking. Small GTPases. Mar 4;9(1-2):1-4
  9. El Hamrani D, Chepied A, Même W, Mesnil M, Defamie N, Même S (2018). Gestational and lactational exposure to dichlorinated bisphenol A induces early alterations of hepatic lipid composition in mice. MAGMA. Feb 20
  10. Boucher J, Monvoisin A, Vix J, Mesnil M, Thuringer D, Debiais F, Cronier L (2018). Connexins, important players in the dissemination of prostate cancer cells. Biochim Biophys Acta. Jan;1860(1):202-215.
  11. Mesnil M, Aasen T, Boucher J, Chépied A, Cronier L, Defamie N, Kameritsch P, Laird DW, Lampe PD, Lathia JD, Leithe E, Mehta PP, Monvoisin A, Pogoda K, Sin WC, Tabernero A, Yamasaki H, Yeh ES, Dagli MLZ, Naus CC (2018). An update on minding the gap in cancer. Biochim Biophys Acta. Jan;1860(1):237-243.
  12. Leithe E, Mesnil M, Aasen T (2018). The connexin 43 C-terminus: A tail of many tales. Biochim Biophys Acta. Jan;1860(1):48-64.
  13. Fourbon Y, Guéguinou M, Félix R, Constantin B, Uguen A, Fromont G, Lajoie L, Magaud C, Lecomte T, Chamorey E, Chatelier A, Mignen O, Potier-Cartereau M, Chantôme A, Bois P, Vandier C. (2017) Ca2+ protein alpha 1D of CaV1.3 regulates intracellular calcium concentration and migration of colon cancer cells through a non-canonical activity. Rep. Oct 27;7(1):14199.
  14. Sarrouilhe D, Dejean C, Mesnil M (2017). Connexin43- and Pannexin-Based Channels in Neuroinflammation and Cerebral Neuropathies. Front Mol Neurosci. Oct 10;10:320.
  15. Aasen T, Mesnil M, Naus C, Lampe PD, Laird DW. (2017) Gap junctions and cancer: Communicating for 50 years. Nature Reviews Cancer. Jan;17(1):74. (IF: 37.4)
  16. Mignen O, Constantin B, Potier-Cartereau M, Penna A, Gautier M, Guéguinou M, Renaudineau Y, Shoji KF, Félix R, Bayet E, Buscaglia P, Debant M, Chantôme A, Vandier C. (2017) constitutive calcium entry and cancer: updated views and insights. Biophys. J. Jul;46(5):395-413.
  17. Thuringer D, Chanteloup G, Boucher J, Pernet N, Boudesco C, Jego G, Chatelier A, Bois P, Gobbo J, Cronier L, Solary E, Garrido C (2017). Modulation of the inwardly rectifying potassium channel Kir4.1 by the pro-invasive miR-5096 in glioblastoma cells. Oncotarget. Jun 6;8(23):37681-37693
  18. Yefimova M, Béré E, Cantereau-Becq A, Harnois T, Meunier AC, Messaddeq N, Becq F, Trottier Y, Bourmeyster N. (2016) Myelinosomes act as natural secretory organelles in sertoli cells to prevent accumulation of aggregate-prone mutant huntingtin and CFTR. Mol. Genet. 2016 Oct 1;25(19):4170-4185. (IF: 5.98)
  19. Crespin S, Fromont G, Wager M, Levillain P, Monvoisin A, Cronier L, Defamie N, Mesnil M. (2016) Expression of a gap junction protein, connexin43, in a large panel of human gliomas: new insights. Cancer Medicine. Aug;5(8):1742-52. (IF: 2.5)
  20. Vedrenne N, Sarrazy V, Battu S, Bordeau N, Richard L, Billet F, Coronas V, Desmoulière A. (2016) Neural stem cell properties of an astrocyte subpopulation sorted by sedimentation field-flow fractionation. Rejuvenation Res. Epub Mar 16 (IF : 3.66)
  21. Aguettaz E, Lopez JJ, Krzesiak A, Cognard C, Constantin B, Sebille S. (2016) Axial stretch-dependent calcium increases in dystrophic cardiomyopathy Cell Calcium, Data In Brief, Aug 10;8:1443-7 (IF: 3.5)
  22. Aguettaz E, Lopez JJ, Krzesiak A, Lipskaia L, Adnot S, Hajjar RJ, Cognard C, Constantin B, Sebille S. (2016) Axial stretch-dependent cation entry in dystrophic cardiomyopathy: involvement of several TRPs channels. Cell Calcium Apr;59(4):145-55. (IF: 3.5)
  23. Guéguinou M, Harnois T, Crottes D, Uguen A, Deliot N, Gambade A, Chantôme A, Haelters J-P, Jaffrès PA, Jourdan ML, Weber G, Soriani O, Bougnoux P, Mignen O, Bourmeyster N, Constantin B, Lecomte T, Vandier C, Potier-Cartereau M. (2016) SK3/TRPC1/Orai1complex regulates SOCE- dependent colon cancer cell migration: a novel opportunity to modulate Anti-EGFR mAb action by the alkyl-lipid Ohmline. Jun 14;7(24):36168-36184. (IF: 6.359).
  24. Basbous S, Levescot A, Piccirilli N, Brizard F, Guilhot F, Roy L, Bourmeyster N, Gombert JM, Herbelin A (2016). The Rho-ROCK pathway as a new pathological mechanism of innate immune subversion in chronic myeloid leukaemia. J Pathol. Nov;240(3):262-268.
  25. Constantin B. (2016) Role of scaffolding proteins in the regulation of TRPC-dependent calcium entry. Exp. Med. Biol.;898:379-403. (IF: 1.9).
  26. Mokrani A, Krisa S, Cluzet S, Da Costa G, Temsamani H, Renouf E, Mérillon JM, Madani K, Mesnil M, Monvoisin A, Richard T. (2016) Phenolic contents and bioactive potential of peach fruit extracts. Food Chem. Jul 1;202:212-20. (IF: 3.4)
  27. Thuringer D, Boucher J, Jego G, Pernet N, Cronier L, Hammann A, Solary E, Garrido C. Transfer of functional microRNAs between glioblastoma and microvascular endothelial cells through gap junctions. (2016) Oncotarget. Nov 8;7(45):73925-73934.
  28. .Déliot N., Constantin B. (2015) Plasma membrane calcium channels in cancer: alterations and consequences for cell proliferation and migration. BBA Biomembranes. Volume 1848, Issue 10, Part B, Pages 2512–2522. (IF: 3.8)
  29. Mercier A, Clément R, Harnois T, Bourmeyster N, Bois P, Chatelier A. (2015) Nav1.5 channels can reach the plasma membrane through distinct N-glycosylation states. BBA General Subject, 1850(6): 1215-23. (IF: 4.4)
  30. Ginisty A, Gély-Pernot A, Abaamrane L, Morel F, Arnault P, Coronas V, Benzakour O. (2015) Evidence for a subventricular zone neural stem cell phagocytic activity stimulated by the vitamin K-dependent factor protein S.Stem Cells. Feb;33(2):515-25. (IF: 7.5)
  31. Segura S, Efthimiadi L, Porcher C, Courtes S, Coronas V, Krantic S, Moyse E. (2015) Leptin-dependent neurotoxicity via induction of apoptosis in adult rat neurogenic cells. Cell Neurosci. Sep 7; 9:350. (IF: 4.2)
  32. Hervé JC, Bourmeyster N. (2015) Rho GTPases at the crossroad of signaling networks in mammals. Small GTPases. 6(2):43-8.
  33. Bassil F, Monvoisin A, Canron MH, Vital A, Meissner WG, Tison F, Fernagut PO. (2015) Region-Specific Alterations of Matrix Metalloproteinase Activity in Multiple System Atrophy. Disord. Nov;30(13):1802-12. (IF: 5.68)
  34. Cochaud S, Meunier AC, Monvoisin A, Bensalma S, Muller JM, Chadéneau C. (2015) Neuropeptides of the VIP family inhibit glioblastoma cell invasion. NeuroOncol. 122: 63-73. 2015. (IF: 3.214)
  35. Sarrouilhe D, Clarhaut J, Defamie N, Mesnil M. Serotonin and cancer: what is the link? (2015) Mol. Med. 15: 62-77. (IF: 3.6)
  36. Sirnes S1, Lind GE, Bruun J, Fykerud TA, Mesnil M, Lothe RA, Rivedal E, Kolberg M, Leithe E. Connexins in colorectal cancer pathogenesis. (2015) J. Cancer. 137: 1-11. (IF: 5.085)
  37. Thuringer D, Berthenet K, Cronier L, Solary E, Garrido C. (2015) Primary tumor- and metastasis-derived colon cancer cells differently modulate connexin expression and function in human capillary endothelial cells. Oct 6;6(30):28800-15 (IF: 6.359)
  38. Thuringer D, Berthenet K, Cronier L, Jego G, Solary E, Garrido C. Oncogenic extracellular HSP70 disrupts the gap-junctional coupling between capillary cells. Apr 30;6(12):10267-83. (IF: 6.359)
  39. Edmond V, Dufour F, Poiroux G, Shoji K, Malleter M, Fouqué A, Tauzin S, Rimokh R, Sergent O, Penna A, Dupuy A, Levade T, Theret N, Micheau O, Ségui B, Legembre P. Downregulation of ceramide synthase-6 during epithelial-to-mesenchymal transition reduces plasma membrane fluidity and cancer cell motility. Oncogene. Feb 19;34(8):996-1005.(IF: 8.459)
  40. Constantin B. (2014) Dystrophin complex functions as a scaffold for signaling proteins. BBA Biomembranes Feb; 1838(2):635-42. (IF: 3.8)
  41. Hervé JC, Derangeon M, Sarrouilhe D, Bourmeyster N. (2014) Influence of the scaffolding protein Zonula Occludens (ZOs) on membrane channels. BBA Biomembranes Feb; 1838(2):595-604. (IF: 3.8)
  42. Defamie N, Chepied A, Mesnil M. (2014) Connexins, gap junctions and tissue invasion. FEBS Lett. 588: 1331-1338. (IF: 3.169)
  43. Sarrouilhe D, Dejean C, Mesnil M. Involvement of gap junction channels in the pathophysiology of migraine with aura. (2014) Physiol. Feb 25;5:78. (IF: 3.5)
  44. Rochelle T., Daubon T, Van Troys M., Harnois T., Waterschoot D., Ampe C., Roy L., Bourmeyster N., Constantin B. (2013) p210bcr-abl induces amoeboid motility by recruiting ADF/destrin activity through RhoA/ROCK1. FASEB J., Jan; 27(1):123-34. (IF: 5.6)
  45. Agasse F, Xapelli S, Coronas V, Christiansen SH, Rosa AI, Sardá-Arroyo L, Santos T, Ferreira R, Schitine C, Harnois T, Bourmeyster N, Bragança J, Bernardino L, Malva JO, Woldbye DP. (2013) Galanin promotes neuronal differentiation in murine subventricular zone cell cultures. Stem cells and Development, 22: 1693-708. (IF: 4)
  46. Legigan T, Clarhaut J, Renoux B, Tranoy-Opalinski I, Monvoisin A, Jayle C, Alsarraf J, Thomas M, Papot S. (2013) Synthesis and biological evaluations of a monomethylauristatin E glucuronide prodrug for selective cancer chemotherapy. J. Med. Chem. 67: 75-80. (IF: 3.447)
  47. Clarhaut J, Fraineau S, Guilhot J, Tranoy-Opalinski I, Thomas M, Renoux B, Peraudeau E, Randriamalala E, Bois P, Chatelier A, Monvoisin A, Cronier L, Papot S, Guilhot F. A (2013) Galactosidase-Responsive Doxorubicin-Folate Conjugate for Selective Targeting of Acute Myelogenous Leukemia Blasts. Leukemia Research, 37: 948-955. (IF: 2.9)
  1. Harisseh R, Chatelier A, Magaud C, Déliot N, Constantin B. (2013) Involvement of TRPV2 and SOCE in calcium influx disorder in DMD primary human myotubes with a specific contribution of a1-syntrophin and PLC/PKC in SOCE regulation. American Journal of Physiology: Cell Physiology, 304(9):C881-94. (IF: 3.8)
  1. Roodhart JM, He H, Daenen LG, Monvoisin A, Barber CL, van Amersfoort M, Hofmann JJ, Radtke F, Lane TF, Voest EE, Iruela-Arispe ML. (2013) Notch1 regulates angio-supportive bone marrow-derived cells in mice: relevance to chemoresistance. 122: 143-153. 2013. (IF: 10.452)
  2. Thuringer D, Jego G, Wettstein G, Terrier O, Cronier L, Yousfi N, Hébrard S, Bouchot A, Hazoumé A, Joly AL, Gleave M, Rosa-Calatrava M, Solary E, Garrido C. (2013) Extracellular HSP27 mediates angiogenesis through Toll-like receptor 3. FASEB J. 27: 4169-4183. (IF: 5.043)
  3. Yefimova MG, Messaddeq N, Harnois T, Meunier AC, Clarhaut J, Noblanc A, Weickert JL, Cantereau A, Philippe M, Bourmeyster N, Benzakour O. (2013) A chimerical phagocytosis model reveals the recruitment by Sertoli cells of autophagy for the degradation of ingested illegitimate substrates. 9: 653-66 (IF: 11.753)
  4. Edmond V, Ghali B, Penna A, Taupin J-L, Daburon S, Moreau J-F, Legembre P. (2012) Precise Mapping of the CD95 Pre-Ligand Assembly Domain. Plos One 7(9):e46236 (equally contributing authors) (IF: 3.234)
  5. Sabourin J., Harisseh R., Harnois T., Magaud C., Bourmeyster N., Déliot N. and Constantin B. (2012) Dystrophin/Alpha1-syntrophin scaffold regulated PLC/PKC-dependent store-operated calcium entry in myotubes. Cell Calcium. Dec; 52(6): 445-56. (IF: 3.8)
  6. Mercier A, Clement R, Harnois T, Bourmeyster N, Faivre JF, Findlay I, Chahine M, Bois P, Chatelier A. (2012) The β(1)-Subunit of Na(v)1.5 Cardiac Sodium Channel Is Required for a Dominant Negative Effect through α-α PLos One 7(11):e48690. (IF: 4.4)
  7. Gely-Pernot A, Coronas V, Harnois T, Prestoz L, Mandairon N, Didier A, Berjeaud JM, Monvoisin A, Bourmeyster N, de Frutos PG, Philippe M, Benzakour O. (2012) An Endogenous Vitamin K-Dependent Mechanism Regulates Cell Proliferation in the Brain Subventricular Stem Cell Niche. Stem Cells, 30: 719-731. (IF: 7.5)
  8. Defamie N, Mesnil M. (2012) The modulation of gap-junctional intercellular communication by lipid rafts. Biophys. Acta. 1818: 1866-1869. 2012. (IF: 3.836)
  9. Fraineau S, Monvoisin A, Clarhaut J, Talbot J, Simonneau C, Kanthou C, Kanse SM, Philippe M, Benzakour O. (2012) The vitamin K-dependent anticoagulant factor, protein S, inhibits multiple VEGF-A-induced angiogenesis events in a Mer- and SHP2-dependent manner. Blood 120: 5073-5083. (IF: 10.452)
  10. Lamiche C, Clarhaut J, Strale PO, Crespin S, Pedretti N, Bernard FX, Naus CC, Chen VC, Foster LJ, Defamie N, Mesnil M, Debiais F, Cronier L. (2012) The gap junction protein Cx43 is involved in the bone-targeted metastatic behaviour of human prostate cancer cells. Exp. Metastasis. 29: 111-122. (IF: 3.491)
  11. Legigan T, Clarhaut J, Tranoy-Opalinski I, Monvoisin A, Renoux B, Thomas M, Le Pape A, Lerondel S, Papot S. (2012) The first generation of β-galactosidase-responsive prodrugs designed for the selective treatment of solid tumors in prodrug monotherapy. Chem. Int. Ed. Engl. 51: 11606-11610. (IF: 11.261)
  12. Legigan T, Clarhaut J, Renoux B, Tranoy-Opalinski I, Monvoisin A, Berjeaud JM, Guilhot F, Papot S. (2012) Synthesis and antitumor efficacy of a β-glucuronidase-responsive albumin-binding prodrug of doxorubicin. Med. Chem. 55: 4516-4520. (IF: 5.45)
  13. Sin WC, Crespin S, Mesnil M. (2012) Opposing roles of connexin43 in glioma progression. BBA Biomembrane 1818: 2058-2067. (IF 3.8)
  14. Strale PO, Clarhaut J, Lamiche C, Cronier L, Mesnil M, Defamie N. (2012) Down-regulation of Connexin43 expression reveals the involvement of caveolin-1 containing lipid rafts in human U251 glioblastoma cell invasion Carcinog. 51: 845-860. (IF: 4.8)
  15. Hervé JC, Derangeon M, Sarrouilhe D, Giepmans BN, Bourmeyster (2012) Gap junctional channels are parts of multiprotein complexes. BBA Biomembrane Aug; 1818(8): 1844-65 (IF: 3.8)
  16. Thiriet N, Agasse F, Nicoleau C, Guégan C, Vallette F, Cadet JL, Jaber M, Malva JO and Coronas V. (2011) NPY promotes chemokinesis and neurogenesis in the rat subventricular zone. Neurochem. 116, 1018-1027. (IF: 3.9)
  17. Zuellig R.A., Bornhauser B.C., Amstutz R., Constantin B, Schaub M.C. (2011) Tissue expression and actin binding of a novel N-terminal utrophine isoforme. Journal of Biomedicine and Biotechnology. (IF: 3.1)
  18. Dominguez C1, Karayan-Tapon L, Desurmont T, Gibelin H, Crespin S, Fromont G, Levillain P, Bouche G, Cantereau A, Mesnil M, Kraimps JL. (2011) Altered expression of the gap junction protein connexin43 is associated with papillary thyroid carcinomas when compared with other noncancer pathologies of the thyroid. 21: 1057-1066. (IF: 4.493)
  19. Grinda M, Clarhaut J, Tranoy-Opalinski I, Renoux B, Monvoisin A, Cronier L, Papot S. (2011) A heterodimeric glucuronide prodrug for cancer tritherapy: the double role of the chemical amplifier. ChemMedChem. 6: 2137-2141. (IF: 2.968)
  20. Khadra N, Bresson-Bepoldin L, Penna A, Chaigne-Delalande B, Ségui B, Levade T, Vacher AM, Reiffers J, Ducret T, Moreau JF, Cahalan MD, Vacher P, Legembre P. (2011) CD95 triggers Orai1-mediated localized Ca2+ entry, regulates recruitment of protein kinase C (PKC) b2, and prevents death-inducing signaling complex formation. PNAS. Nov 22;108(47):19072-7 (equally contributing authors) (IF: 9.681)
  21. Demuro A, Penna A, Safrina O, Yeromin AV, Amcheslavsky A, Cahalan MD, Parker I. (2011) Subunit stoichiometry of human Orai1 and Orai3 channels in closed and open states. PNAS. Oct 25; 108(43):17832-7. (IF: 9.681)


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